Inicio > SANTO DOMINGO MAYORAL, JAIME

SANTO DOMINGO MAYORAL, JAIME

INVESTIGADOR DISTINGUIDO SENIOR
Bioquímica y Biología Molecular y Fisiología
Transporte Iónico Celular
 
jaime.santo-domingo@uva.es

Índice H en Scopus: 15
 

[][com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=80631]], camposKey:2213-2317 2023-08-01 The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=77887]], camposKey:1663-9812 2023-01-01 SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=80436]], camposKey:0021-9533 2023-01-01 SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=76122]], camposKey:0021-9258 2022-03-01 Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=76078]], camposKey:2227-9059 2022-02-01 Modeling Alzheimer¿s Disease in Caenorhabditis elegans00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58967]], camposKey:0007-1188 2021-05-01 Mitochondrial ion channels in pancreatic beta-cells: Novel pharmacological targets for the treatment of Type 2 diabetes20772095, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58986]], camposKey:0012-186X 2020-12-01 Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells26282640, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58987]], camposKey:1756-8919 2020-09-01 Targeting mitochondrial ion channels in Type 2 diabetes15251527, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58968]], camposKey:0022-2836 2020-03-06 Protein Lysine Acetylation: Grease or Sand in the Gears of beta-Cell Mitochondria?14461460, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58969]], camposKey:0007-1188 2019-09-01 The plant product quinic acid activates Ca2+-dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells32503263, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58970]], camposKey:0892-6638 2019-04-01 Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin-secreting cells46604674, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58971]], camposKey:1478-811X 2019-02-20 Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58972]], camposKey:0303-7207 2019-02-05 Cellular stress is a prerequisite for glucose-induced mitochondrial matrix alkalinization in pancreatic beta-cells7183, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=49894]], camposKey:0143-4160 2019-01-01 Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators6876, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58973]], camposKey:0014-4827 2017-08-15 Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic beta-cells170180, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58974]], camposKey:0021-9533 2017-06-01 A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells19291939, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58975]], camposKey:2045-2322 2017-05-09 Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation (Vol 7, Pg 45961, 2017)00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58976]], camposKey:2045-2322 2017-04-12 Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58978]], camposKey:0892-6638 2017-03-01 Coordinated activation of mitochondrial respiration and exocytosis mediated by PKC signaling in pancreatic beta cells10280, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58977]], camposKey:1469-221X 2017-03-01 L-OPA1 regulates mitoflash biogenesis independently from membrane fusion451463, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58979]], camposKey:0892-6638 2016-05-01 Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems19131926, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58988]], camposKey:0021-9258 2014-01-01 NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state2037720385, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58980]], camposKey:0261-4189 2013-07-03 OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange19271940, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58981]], camposKey:0005-2728 2012-10-01 NCLX, but not Letm1, mediates matrix Ca2+ extrusion and modulates the mitochondrial redox state during HeLa cell stimulation00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58982]], camposKey:0022-1295 2012-06-01 The renaissance of mitochondrial pH415423, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58983]], camposKey:1398-9219 2011-05-01 Securin and Separase Modulate Membrane Traffic by Affecting Endosomal Acidification615626, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58989]], camposKey:0021-9258 2011-04-01 Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations1167211684, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58984]], camposKey:0005-2728 2010-07-01 pH Spikes in individual mitochondria119120, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58985]], camposKey:0005-2728 2010-06-01 Calcium uptake mechanisms of mitochondria907912, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1078]], camposKey:1047-8477 2010-01-01 A confocal study on the visualization of chromaffin cell secretory vesicles with fluorescent targeted probes and acidic dyes261269, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1086]], camposKey:0272-4340 2010-01-01 Ca2+ Dynamics in the Secretory Vesicles of Neurosecretory PC12 and INS1 Cells12671274, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=2761]], camposKey:0363-6143 2009-01-01 MaxiK potassium channels in the function of chemoreceptor cells of the rat carotid body00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1103]], camposKey:0953-816X 2008-01-01 Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules12651274, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=6971]], camposKey:0005-2728 2008-01-01 Mitochondrial free [Ca2+] and the permeability transition pore00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1070]], camposKey:0022-3751 2007-01-01 Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation3949, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1064]], camposKey:0007-1188 2007-01-01 The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter647654, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1071]], camposKey:0143-4160 2006-01-01 The mitochondrial Na+/Ca2+ exchanger plays a key role in the control of cytosolic Ca2+ oscillations5361, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1097]], camposKey:0143-4160 2005-01-01 Calcium dynamics in catecholamine-containing secretory vesicles555564, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1066]], camposKey:0007-1188 2005-01-01 Modulation of mitochondrial Ca2+ uptake by estrogen receptor agonists and antagonists862871, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=1067]], camposKey:0264-6021 2004-01-01 Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids1924, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=6967]], camposKey:0005-2728 2004-01-01 Modulation of the mitochondrial Ca2+ uniporter4040][][][][][][][com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=64221]], com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=64037]], com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=61044]]][com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=64221]], com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=64037]], com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBeca[id=com.sigma.fs3.argos.domain.gpc.GpcAltresAjutsBecaPK[ifcactivitat=AAB, ifccomptador=61044]]][][][][][][][][][][][][][][][][][][][][][com.sigma.investigacion.cawdos.entities.ayudaInvestigacion.ProjectesPPC[id=com.sigma.fs3.argos.domain.gpc.ayudasrecerca.ProjectesPPCId@56f24f], com.sigma.investigacion.cawdos.entities.ayudaInvestigacion.ProjectesPPC[id=com.sigma.fs3.argos.domain.gpc.ayudasrecerca.ProjectesPPCId@411d3f], com.sigma.investigacion.cawdos.entities.ayudaInvestigacion.ProjectesPPC[id=com.sigma.fs3.argos.domain.gpc.ayudasrecerca.ProjectesPPCId@412194], com.sigma.investigacion.cawdos.entities.ayudaInvestigacion.ProjectesPPC[id=com.sigma.fs3.argos.domain.gpc.ayudasrecerca.ProjectesPPCId@411f8e]][][][][][][com.sigma.fs3.argos.domain.gpc.altres.ProjecteInnovacio@17069][]

AYUDA A LA INVESTIGACIÓN

PUBLICACIONES

Artículos de revista (41)

Weiser A.; Hermant A.; Bermont F.; Sizzano F.; Karaz S.; Alvarez-Illera P.; Santo-Domingo J.; Sorrentino V.; Feige J.N.; De Marchi U. The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state . REDOX BIOLOGY 2023; 64.

Enlace a la publicación
Ver Todos
 

AYUDA A LA INVESTIGACIÓN

Proyectos (4)

SEÑALIZACIÓN POR Ca2+: UNA NUEVA DIANA PARA ACTUAR SOBRE EL ENVEJECIMIENTO Y LAS ENFERMEDADES NEURODEGENERATIVAS. Equipo Investigadores: ALVAREZ MARTIN, JAVIER (IP); MONTERO ZOCCOLA, MARIA TERESA (IP); SANTO DOMINGO MAYORAL, JAIME; FONTERIZ GARCIA, ROSALBA INES. Equipo de Trabajo: ALVAREZ ILLERA, MARIA PILAR; ROMERO SANZ, SILVIA; CALDERO ESCUDERO, ELENA. Personal Contratado: ALVAREZ ILLERA, MARIA PILAR. PID2021-122239OB-I00. Entidades Participantes: UNIVERSIDAD DE VALLADOLID (UVa). Entidades Financiadoras: AGENCIA ESTATAL DE INVESTIGACIÓN, FONDOS FEDER, UNION EUROPEA, MICINN. MINISTERIO DE CIENCIA E INNOVACIÓN . 01/09/2022-31/08/2026

FEDERUnión EuropeaMnisterio de Ciencia e InnovaciónAEI
Ver Todos

Otras ayudas y becas (3)

CONTRATO PREDOCTORAL UVA DE CALDERO ESCUDERO, ELENA. SENUVA1. SANTO DOMINGO MAYORAL, JAIME (Director). CALDERO ESCUDERO, ELENA (Beneficiario). 01/05/2023 - 30/04/2027. 94.700,76 EUR.

Banco SantanderUniversidad de Valladolid
Ver Todos
 
Cargando información ...
Universidad de Valladolid - Copyright Universidad de Valladolid - Todos los derechos reservados