Inicio > COZAR CASTELLANO, IRENE

COZAR CASTELLANO, IRENE

PROFESORES TITULARES DE UNIVERSIDAD
Bioquímica y Biología Molecular y Fisiología
Enfermedades Metabólicas y Neurodegeneración
 
irene.cozar@uva.es

Índice H en Scopus: 24
 

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J. Biochem. Cell Biol. 38C (2006) 931¿950](S1357272507001768)(10.1016/j.biocel.2007.05.023)00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58948]], camposKey:0026-0495 2020-12-01 Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54831]], camposKey:1064-3745 2020-01-01 Assessment of Insulin Tolerance Ex Vivo291300, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54832]], camposKey:1064-3745 2020-01-01 Assessment of Insulin Tolerance In Vivo in Mice217224, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54833]], camposKey:2072-6643 2020-01-01 Intestinal fructose and glucose metabolism in health and disease00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=49247]], camposKey:0213-3911 2019-01-01 Insulin degrading enzyme is up-regulated in pancreatic beta cells by insulin treatment11671180, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=49246]], camposKey:0947-6539 2019-01-01 Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose-Stimulated Insulin Secretion in beta-Cells92879294, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54314]], camposKey:0193-1849 2019-01-01 Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38531]], camposKey:0040-4020 2018-01-01 Cembranoids from Eunicea sp. enhance insulin-producing cells proliferation20562062, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38532]], camposKey:1660-3397 2018-01-01 Chloro-furanocembranolides from Leptogorgia sp. 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com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38542]], camposKey:1932-6203 2013-01-01 Correction: Epoxypukalide induces proliferation and protects against cytokine-mediated apoptosis in primary cultures of pancreatic ß-cells (PLoS ONE)00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38540]], camposKey:0306-4530 2013-01-01 Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice24622475, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38543]], camposKey:1932-6203 2013-01-01 Epoxypukalide Induces Proliferation and Protects against Cytokine-Mediated Apoptosis in Primary Cultures of Pancreatic ß-Cells00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38541]], camposKey:0193-1849 2013-01-01 High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40316]], camposKey:0012-1797 2013-01-01 Insulin-Degrading Enzyme Is Necessary for Pancreatic Beta-Cell Glucose-Stimulated Insulin Secretion00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40317]], camposKey:0012-1797 2013-01-01 The Hepatocyte Growth Factor Is Elevated in Amniotic Fluid from Obese Women and Regulates Placental Glucose and Fatty Acid Metabolism00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40319]], camposKey:1742-464X 2012-01-01 Hepatocyte Growth Factor and skeletal muscle insulin resistance268268, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38545]], camposKey:0193-1849 2012-01-01 Increased Aß production prompts the onset of glucose intolerance and insulin resistance00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38544]], camposKey:1932-6203 2012-01-01 Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38546]], camposKey:0939-5555 2012-01-01 Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells.8388, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40320]], camposKey:0012-186X 2011-01-01 A mouse model of Alzheimer's disease develops insulin resistance00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=843]], camposKey:0026-0495 2011-01-01 Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia17671774, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38547]], camposKey:0012-1797 2010-08-01 Induction of human ß-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk619261936, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40324]], camposKey:0012-1797 2010-01-01 Combined Genetic Loss of the Cell Cycle Inhibitors, p21cip1 and p27kip1, Reveals That Both Are Dispensable for Adult Beta Cell Proliferation, Mass and Function00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40322]], camposKey:0163-769X 2010-01-01 Comprehensive Upstream Regulatory Exploration Reveals That cMyc Is a Key Regulator of Proliferation in Both Commonly Employed Rat Insulinoma Cell Lines.00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40325]], camposKey:0012-186X 2009-01-01 Combined loss of the cell cycle inhibitors p21cip1 and p27kip1 reveals that both are dispensable for maintaining adult beta cell mass and function00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38549]], camposKey:0013-7227 2009-01-01 Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation 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com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38556]], camposKey:0012-1797 2006-01-01 Evaluation of ß-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: Comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21 cip7077, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38555]], camposKey:1357-2725 2006-01-01 Growth factors and beta cell replication931950, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38554]], camposKey:0163-769X 2006-01-01 Molecular control of cell cycle progression in the pancreatic ß-cell356370, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38552]], camposKey:0012-1797 2006-01-01 The cell cycle inhibitory protein p21cip is not essential for maintaining ß-cell cycle arrest or ß-cell function in vivo32713278, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=30765]], camposKey:0027-8424 2005-01-01 Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy77817782, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38557]], camposKey:1699-258X 2005-01-01 The search for new autoantigens in Sjögren's syndrome Búsqueda de nuevos autoantígenos en el síndrome de Sjögren187192, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40318]], camposKey:1471-2598 2004-01-01 Hepatocyte growth factor gene therapy for islet transplantation507518, 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Artículos de revista (65)

Corraliza-Gomez M.; Bermejo T.; Lilue J.; Rodriguez-Iglesias N.; Valero J.; Cozar-Castellano I.; Arranz E.; Sanchez D.; Ganfornina M.D. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer¿s disease and brain aging . JOURNAL OF NEUROINFLAMMATION 2023; 20(1).

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Libros (4)

Merino Antolin, Beatriz; Bayon Prieto, Yolanda; Cozar Castellano, Irene. Fisiología del sistema endocrino. Ediciones Universidad de Valladolid; 2021.
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AYUDA A LA INVESTIGACIÓN

Proyectos (12)

PAPEL DE INSULIN-DEGRADING ENZYME EN EL EJE TUBULINA-CILIO PRIMARIO PARA LA REGULACIÓN DE LA SECRECIÓN DE INSULINA Y GLUCAGÓN. Equipo Investigadores: COZAR CASTELLANO, IRENE (IP). Equipo de Trabajo: CASANUEVA ALVAREZ, ELENA; MERINO ANTOLIN, BEATRIZ; SANZ GONZALEZ, ALBA; GONCALVES RAMIREZ, ARIANNA CAROLINA; HERNÁNDEZ DE LA RED, SILVIA. Personal Contratado: GONCALVES RAMIREZ, ARIANNA CAROLINA. PID2022-136605OB-C21. Entidades colaboradoras AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC). Entidades Participantes: UNIVERSIDAD DE VALLADOLID (UVa). Entidades Financiadoras: AGENCIA ESTATAL DE INVESTIGACIÓN, FONDOS FEDER, 10.13039/501100011033, UNION EUROPEA, MICINN. MINISTERIO DE CIENCIA E INNOVACIÓN . 01/09/2023-31/08/2026

FEDERUnión EuropeaMnisterio de Ciencia e InnovaciónAEI
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Convenios/Contratos OTC (4)

INVESTIGACION PARA LA DIABETES. . Equipo Investigadores: COZAR CASTELLANO, IRENE (IP). Entidades Participantes: FUNDACION GENERAL DE LA UNIVERSIDAD DE VALLADOLID.. Entidades Financiadoras: ASOCIACIÓN DE LA PRENSA DEPORTIVA DE VAL., ASOCIACION CULTURAL CEPA HUERTA DEL REY.. 21/01/2021

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Otras ayudas y becas (11)

CONTRATO PREDOCTORAL MINECO (FPI) DE SILVIA HERNÁNDEZ DE LA RED: FUNCIONES NO PROTEOLÍTICAS DE IDE EN HÍGADO Y PÁNCREAS ENDOCRINO. COZAR CASTELLANO, IRENE (Director). HERNÁNDEZ DE LA RED, SILVIA (Beneficiario). 01/02/2024 - 31/01/2028. 133.405,28 EUR.

FSE+Mº Ciencia, Innovación y UniversidadesAEIUniversidad de Valladolid
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OTROS

Tesis doctorales (6)

CASANUEVA ALVAREZ, ELENA Role of insulin-degrading enzyme in pancreatic alpha-cell function.. Universidad de Valladolid; 2024

 
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Congresos (2)

ASISTENCIA AL CONGRESO DE LA SOCIEDAD AMERICANA DE DIABETES, SAN DIEGO ( ESTADOS UNIDOS DE AMÉRICA ) 23/06/2023 -
(Conferencia invitada). COZAR CASTELLANO, IRENE. ASISTENCIA AL CONGRESO DE LA SOCIEDAD AMERICANA DE DIABETES
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Proyectos de innovación docente (5)

Evaluación de la utilidad de los Manuales de Estudiante y materiales didácticos de Fisiología Endocrina y Nerviosa de la UVa en grados internacionales de Ciencias de la Salud - PID2022/27. Universidad de Valladolid. 01/09/2022.
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