Inicio > COZAR CASTELLANO, IRENE

COZAR CASTELLANO, IRENE

PROFESORES TITULARES DE UNIVERSIDAD
Bioquímica y Biología Molecular y Fisiología
ENFERMEDADES METABÓLICAS Y NEURODEGENERACIÓN
 
irene.cozar@uva.es

Índice H en Scopus: 23
 

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Cell Biol. 38C (2006) 931¿950](S1357272507001768)(10.1016/j.biocel.2007.05.023)00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=58948]], camposKey:0026-0495 2020-12-01 Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54831]], camposKey:1064-3745 2020-01-01 Assessment of Insulin Tolerance Ex Vivo291300, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54832]], camposKey:1064-3745 2020-01-01 Assessment of Insulin Tolerance In Vivo in Mice217224, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54833]], camposKey:2072-6643 2020-01-01 Intestinal fructose and glucose metabolism in health and disease00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=49247]], camposKey:0213-3911 2019-01-01 Insulin degrading enzyme is up-regulated in pancreatic beta cells by insulin treatment11671180, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=49246]], camposKey:0947-6539 2019-01-01 Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose-Stimulated Insulin Secretion in beta-Cells92879294, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=54314]], camposKey:0193-1849 2019-01-01 Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38531]], camposKey:0040-4020 2018-01-01 Cembranoids from Eunicea sp. enhance insulin-producing cells proliferation20562062, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38532]], camposKey:1660-3397 2018-01-01 Chloro-furanocembranolides from Leptogorgia sp. Improve pancreatic beta-cell proliferation00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38530]], camposKey:0026-0495 2018-01-01 Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice111, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=11439]], camposKey:1660-3397 2017-01-01 Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38536]], camposKey:0306-4530 2015-01-01 Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease6979, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38537]], camposKey:0193-1849 2015-01-01 Cyclin C stimulates ß-cell proliferation in rat and human pancreatic ß-cells00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38538]], camposKey:1687-8337 2015-01-01 Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on ß-Cell Functionality00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38535]], camposKey:1933-7191 2015-01-01 Glucose and fatty acid metabolism in placental explants from pregnancies complicated with gestational diabetes mellitus798801, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38534]], camposKey:0143-4004 2015-01-01 Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism381388, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40315]], camposKey:1938-2014 2015-01-01 Protective effects of epoxypukalide on pancreatic beta-cells and glucose metabolism in STZ-induced diabetic mice00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38533]], camposKey:1138-7548 2015-01-01 Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice795805, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38539]], camposKey:1932-6203 2014-01-01 Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38542]], camposKey:1932-6203 2013-01-01 Correction: Epoxypukalide induces proliferation and protects against cytokine-mediated apoptosis in primary cultures of pancreatic ß-cells (PLoS ONE)00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38540]], camposKey:0306-4530 2013-01-01 Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice24622475, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38543]], camposKey:1932-6203 2013-01-01 Epoxypukalide Induces Proliferation and Protects against Cytokine-Mediated Apoptosis in Primary Cultures of Pancreatic ß-Cells00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38541]], camposKey:0193-1849 2013-01-01 High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40316]], camposKey:0012-1797 2013-01-01 Insulin-Degrading Enzyme Is Necessary for Pancreatic Beta-Cell Glucose-Stimulated Insulin Secretion00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40317]], camposKey:0012-1797 2013-01-01 The Hepatocyte Growth Factor Is Elevated in Amniotic Fluid from Obese Women and Regulates Placental Glucose and Fatty Acid Metabolism00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40319]], camposKey:1742-464X 2012-01-01 Hepatocyte Growth Factor and skeletal muscle insulin resistance268268, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38545]], camposKey:0193-1849 2012-01-01 Increased Aß production prompts the onset of glucose intolerance and insulin resistance00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38544]], camposKey:1932-6203 2012-01-01 Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38546]], camposKey:0939-5555 2012-01-01 Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells.8388, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40320]], camposKey:0012-186X 2011-01-01 A mouse model of Alzheimer's disease develops insulin resistance00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=843]], camposKey:0026-0495 2011-01-01 Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia17671774, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38547]], camposKey:0012-1797 2010-08-01 Induction of human ß-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk619261936, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40324]], camposKey:0012-1797 2010-01-01 Combined Genetic Loss of the Cell Cycle Inhibitors, p21cip1 and p27kip1, Reveals That Both Are Dispensable for Adult Beta Cell Proliferation, Mass and Function00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40322]], camposKey:0163-769X 2010-01-01 Comprehensive Upstream Regulatory Exploration Reveals That cMyc Is a Key Regulator of Proliferation in Both Commonly Employed Rat Insulinoma Cell Lines.00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40325]], camposKey:0012-186X 2009-01-01 Combined loss of the cell cycle inhibitors p21cip1 and p27kip1 reveals that both are dispensable for maintaining adult beta cell mass and function00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38549]], camposKey:0013-7227 2009-01-01 Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15 Ink4b and p27 kip114291439, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38548]], camposKey:0012-1797 2009-01-01 Survey of the human pancreatic ß-cell G1/S proteome reveals a potential therapeutic role for dk-6 and Cyclin D 1 in Enhancing Human ß-cell replication and function in vivo882893, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38550]], camposKey:0012-1797 2008-01-01 Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines30563068, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40312]], camposKey:0012-1797 2007-01-01 Comprehensive comparative cell cycle analysis reveals critical differences in human vs. murine beta cell regulation: Human islets contain Cdk-6, but lack Cdk400, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38551]], camposKey:0012-1797 2007-01-01 Tissue-specific deletion of the retinoblastoma protein in the pancreatic ß-cell has limited effects on ß-cell replication, mass, and function5764, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38553]], camposKey:0009-7330 2006-01-01 Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: Definition of an arterial smooth muscle PTHrP/p27kip1 pathway933942, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40313]], camposKey:0012-1797 2006-01-01 Conditional knockout of the retinoblastoma (pRb) gene in beta cells has no effect on beta cell mass or function00, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38556]], camposKey:0012-1797 2006-01-01 Evaluation of ß-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: Comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21 cip7077, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38555]], camposKey:1357-2725 2006-01-01 Growth factors and beta cell replication931950, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38554]], camposKey:0163-769X 2006-01-01 Molecular control of cell cycle progression in the pancreatic ß-cell356370, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38552]], camposKey:0012-1797 2006-01-01 The cell cycle inhibitory protein p21cip is not essential for maintaining ß-cell cycle arrest or ß-cell function in vivo32713278, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=30765]], camposKey:0027-8424 2005-01-01 Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy77817782, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=38557]], camposKey:1699-258X 2005-01-01 The search for new autoantigens in Sjögren's syndrome Búsqueda de nuevos autoantígenos en el síndrome de Sjögren187192, com.sigma.fs3.argos.domain.gpc.GpcArticlesRev[id=com.sigma.fs3.argos.domain.gpc.GpcArticlesRevPK[ifcactivitat=ARE, ifccomptador=40318]], camposKey:1471-2598 2004-01-01 Hepatocyte growth factor gene therapy for islet transplantation507518, 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Artículos de revista (59)

Arevalo-Martinez M.; Cidad P.; Moreno-Estar S.; Fernandez M.; Albinsson S.; Cozar-Castellano I.; Lopez-Lopez J.R.; Perez-Garcia M.T. miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers . MOLECULAR METABOLISM 2021; 53.

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Libros (4)

Merino Antolin, Beatriz; Bayon Prieto, Yolanda; Cozar Castellano, Irene. Fisiología del sistema endocrino. Ediciones Universidad de Valladolid; 2021.
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AYUDA A LA INVESTIGACIÓN

Proyectos (10)

REGULACIÓN PARACRINA MEDIADA POR IDE DE LA FUNCIÓN DE LAS CÉLULAS DEL ISLOTE PANCREÁTICO. Equipo Investigadores: COZAR CASTELLANO, IRENE (IP); DOMINGUEZ LOBATON, MARIA DEL CARMEN; MERINO ANTOLIN, BEATRIZ. Equipo de Trabajo: FERNANDEZ DIAZ, CRISTINA MARIA; POSTIGO CASADO, TAMARA; CASANUEVA ALVAREZ, ELENA; SANZ GONZALEZ, ALBA; GONCALVES RAMIREZ, ARIANNA CAROLINA. Personal Contratado: MERINO ANTOLIN, BEATRIZ; GONCALVES RAMIREZ, ARIANNA CAROLINA. PID2019-110496RB-C21. Entidades colaboradoras AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC). Entidades Participantes: UNIVERSIDAD DE VALLADOLID (UVa). Entidades Financiadoras: AGENCIA ESTATAL DE INVESTIGACIÓN, 10.13039/501100011033. 01/06/2020-31/05/2023

AEI
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Convenios (4)

INVESTIGACION PARA LA DIABETES. . Equipo Investigadores: COZAR CASTELLANO, IRENE (IP). Entidades Participantes: FUNDACION GENERAL DE LA UNIVERSIDAD DE VALLADOLID.. Entidades Financiadoras: ASOCIACIÓN DE LA PRENSA DEPORTIVA DE VAL., ASOCIACION CULTURAL CEPA HUERTA DEL REY.. 2021-01-21

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Otras ayudas y becas (10)

CONTRATO POSTDOCTORAL UVA MERINO ANTOLÍN, BEATRIZ "NUEVAS TERAPIAS FARMACOLÓGICAS EN EL TRATAMIENTO DE LA HIPERGLUCAGONEMIA ASOCIADA A DIABETES. COZAR CASTELLANO, IRENE (Director). MERINO ANTOLIN, BEATRIZ (Beneficiario). 15/01/2022 - 14/01/2025. 125.705,00 EUR.

Universidad de Valladolid
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OTROS

Tesis doctorales (5)

GONZALEZ CASIMIRO, CARLOS MANUEL Hepatic insulin-degrading enzyme regulation and its role on glucagon signaling. Universidad de Valladolid; 2022

 
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Congresos (1)

AYUDAS UVA A LA INVESTIGACION: 76 CONGRESO DE LA ASOCIACION AMERICANA DE DIABETES, NUEVA ORLEANS ( ESTADOS UNIDOS DE AMÉRICA ) 10/06/2016 -
(Asistencia). COZAR CASTELLANO, IRENE. AYUDAS UVA A LA INVESTIGACION: 76 CONGRESO DE LA ASOCIACION AMERICANA DE DIABETES
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